Biology 2382B Study Guide - Midterm Guide: Transferrin Receptor, Ldl Receptor, Transferrin
19 Aug 2017
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Learning objectives: major steps of receptor-mediated endocytosis. Transferrin cycle: delivery of membrane and cytosolic proteins for degradation in lysosomes. Recommended readings: chapter 14: receptor mediated endocytosis, ldl receptor, transferrin cycle p. 659-664; autophagy p. 667-669. How can cells internalize the extracellular materials? (bringing outside stuff in is really important!: phagocytosis. Your macrophages do this white blood cells. You take the membrane and you encompass a very large particle or another organism. But only few cells can undergo phagocytosis. Not a common thing that all cells do: pinocytosis. You make small vesicles from the plasma membrane. All you bring inside to the cell is liquids. Not all cells undergo pinocytosis: receptor-mediated endocytosis. A method of selective internalization of specific extracellular molecules (ligands) Most cells, if not all cells, undergo receptor-mediated endocytosis. Forming a vesicle at the cell surface and then bringing things into the cell.
