HMB202H1 Study Guide - Final Guide: Lymphadenopathy, Portal Vein, Peripheral Membrane Protein
Document Summary
Etiology means the cause or the nature of the environmental perturbation that leads to disease. We don"t know where along this timeline this irreversible injury occurs. Necrosis is a pattern of tissue death. Irreversible cell injury always leads to cell death. Timeline from the initial stage where oxygen is depleted Sodium and water move into cell; potassium moves out of cell (no atp to drive the na+/k+ pumps) One of the main functions of the liver is lipid metabolism, so if oxygen is taken away, lipids accumulate in the cells. At this stage the condition is reversible if you bring back oxygen. Dual blood supply that merges along the liver sinusoids: from the hepatic artery and hepatic portal vein that exits through the central vein > the hepatic vein. Liver acinus model: under normal conditions the perivenous cells in zone 3 are no different from cells in zone 1 and 2, though they receive the least amount of oxygen.
