BCH210H1 Study Guide - Fall 2018, Comprehensive Midterm Notes - Protein, Side Chain, Protein Structure
12 Oct 2018
School
Course
BCH210H1
MIDTERM EXAM
STUDY GUIDE
Fall 2018
BCH210H1(F) – Lecture 1
• Complex molecules like proteins are built from simple building blocks (amino
acids)
• Example of a protein → Hemoglobin
a. Tetramer of 2 (alpha) and 2 (beta) polypeptide chains
b. Contains heme (see diagram)
c. Globin is a protein
• Disease: Sickle Cell Anemia
Normal cell Sickle cell
a. A single amino acid change (Glu6Val) in the -chain of hemoglobin
causes sickle cell anemia
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i. Glu6Val means that valine (V) replaces glutamate (E) in
position 6 of the beta chain
Glutamate vs. Valine
b. Hb S forms long polymers that change the shape of the red blood
cell
• Biochemistry allows us to understand the molecular basis of life and disease
• Proteins…
a. are polymers of amino acids linked linearly by peptide bonds
b. fold into specific 3-D structures
c. are agents of biological function → often working as enzymes
i. Ex. sucrase catalyzes the hydrolysis of sucrose into fructose
and glucose
d. are encoded by genes
e. can be defective when mutations in genes arise, resulting in
inherited diseases
• Molecules of life:
a. Proteins (e.g., hemoglobin, enzymes)
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49
BCH210H1 Full Course Notes
Verified Note
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