NROC61H3 Study Guide - Final Guide: Autonomic Nervous System, Trpv1, Propranolol
Document Summary
Intracranial self- stimulation: reward: feeling of pleasure accompanies certain acts or experience (hedonic impact) Feeling of anticipation of impending goal: olds & milner: discovered phenomenon of intracranial self-stimulation (icss) Rats level press at 7000press/hr to receive electrical stimulation in certain area. Allow and suggest mapping of neuroanatomy of reward pathway: icss in animal: elicit consummation behaviour (eating), hence icss may related to consummation behaviour, icss response: behaviour will be maintain even long period of extinction is introduced. No tolerance is shown in icss, have accumulation in level-pressing behaviour: icss positive sites: main positive sites for icss are found in medial forebrain bundle across different species. Medial forebrain bundle: complex bundle of axons originate from vta through lh and nacc. Refer as pleasure centre , accompanied by consummatory behaviour when stimulated. Icss of limbic sites: septum, hippocampus, prefrontal cortex and amygdala. Produced lower rates of responding, and less behavioural activation. Icss punishment sites: icss avoided in penriventricular region.
