KIN408 Study Guide - Midterm Guide: Ventricular Hypertrophy, Blood Pressure, Afterload

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Volume of blood ejected per unit time (l/min) Increase sns more pumping higher co. Volume pumped by heart is regulated by: Intrinsic cardiac regulation in response to changes in volume of blood returning to the heart (preload) Control of heart rate (chronotropy) and strength of heart pumping (inotropy) by the ans. Control of the pressure in the aorta (afterload) Esv regulated by afterload and inotropy. Compliance decreases with increasing pressure or volume: ventricles become less compliant/ stiffer in higher volumes, ventricular compliance depends on: Physical properties of the connective tissue of the wall of the ventricle. State of ventricular relaxation: ventricular hypertrophy: increased muscle thickness decreases vent. Compliance ventricular ed pressure is higher for any given edv. Similarly, for a given ed pressure, a less compliant ventricle will have a smaller edv. If lusitropy is impaired, ventricular compliance will be reduced impair v. filling & increase ed pressure.

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