NUTR 4210 Study Guide - Final Guide: Inflammasome, Adiponectin, Hyperinsulinemia

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 4210
• Professor: Lindsay Robinson

Document Summary

Study: as bmi increases, risks of type 2 diabetes and cardiovascular disease increase, but the increase is less steep for mho than for the general population. Study: mho were not at risk for cvd, lean and obese with more than 2 metabolic abnormalities has elevated risk of death, muho also had elevated risk. Study: mho (<2 cvd risk factors) and muho (<2 cvd risk factors) had different body composition (different amount of fat and where it is stored) and thus different cardiometabolic profiles. Inflammasome: multiprotein complex that leads to more inflammatory mediators in adipose when activated. Study: mho and muho again defined by presence of cvd risk factors (already undergoing surgery) More nlrp3 (an inflammasome) more insulin resistance in muho. More expression and secretion of il-1 in visceral adipose of muho. Muho has a less favorable inflammatory profile than mho! Inflammasome may be a useful target in treatment/prevention of obesity induced ir.