BIOM 4030 Study Guide - Midterm Guide: Thyrotropin-Releasing Hormone, Thyroid Peroxidase, Follicular Cell

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 4030
• Professor: Pawel Bartlewski

Document Summary

Paraventricular nucleus of hypothalamus releases trh (peptide, gq-linked receptor with ip3) Thyrotropes in anterior pituitary release tsh (glycoprotein, gs-linked receptor with camp and gq-linked receptor with ip3 and dag) T4 (amino acid, unknown receptor, thyroxine, 4 iodides) and small amount of t3 (amino acid, nuclear receptor, triiodothyronine, 3 iodides) produced. T4 feeds back negatively onto anterior pituitary and hypothalamus to stop trh and tsh release. 1-adrenergic nerves stimulate pre-protrh gene expression and pulsatile release of trh (constant) Trh binds gq-linked receptor in anterior pituitary. Largest gland in the neck (but still relatively small) 10-15g in a dog. Originates from oropharynx around same time as aorta. Folli(cid:272)les (cid:272)o(cid:373)posed of th(cid:455)ro(cid:272)(cid:455)tes surrou(cid:374)di(cid:374)g (cid:272)olloid (cid:894)lu(cid:373)e(cid:374)(cid:895) (cid:449)here th"s are stored. Fewer blood vessels = healthy active thyroid. Exocytosis of tg into lumen of follicle (diffusion down gradient) Tg gets iodinated via thyroid peroxidase (tpo) Vessicles fuse with lysosomes in response to tsh.