BIOM 3090 Study Guide - Final Guide: Nmda Receptor Antagonist, Dopamine Receptor, Nmda Receptor

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

Severe disturbance in brain function normal perceptions of the environment are disrupted. Auditory/visual hallucinations, suspicion, paranoia, attachment of excessive personal significance to daily events. Bizarre behaviour and difficulties with social interactions and adl. Positive likely can be treated with antipsychotic drugs. Can occur at same time as positive. Cocaine or amphetamine use ( dopamine neurotransmission) can schizophrenia-like symptoms; hallucinations = adverse effect of l-dopa. Supports role of dopamine imbalance in psychosis. Hallucinogens: pcp (nmda receptor antagonist) and lsd (5-ht2a agonist) hallucinations, paranoia, panic. Supports role of glutamate & serotonin imbalance in psychosis. Recall neural circuits with glutamate, serotonin, and dopamine, all affect each other. Psychosis and the dopamine hypothesis: antipsychotics block d2 receptors, drugs that dopamine activity aggravate or produce psychosis, dopamine receptor density in schizophrenic patients, dopamine metabolites in successfully treated schizophrenic patients. Dopamine pathways: nigrostriatal associated with movement, cortical: dopamine transmission negative symptoms, limbic: dopamine transmission positive symptoms. Hard because different levels in different regions cause symptoms!