BIOC 2580 Study Guide - Midterm Guide: Edman Degradation, Nucleophilic Substitution, Sanger Sequencing
23 Feb 2017
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Document Summary
A protein is a long linear chain of amino acids. The image is an accurate representation of the structure of myoglobin. The linear chain of myoglobin is precisely folded into a compact, 3-dimensional globular structure. A simplified view shows distinct regular patterns in folded protein. The ribbon traces the path of the polypeptide backbone (peptide bonds only, no side chains) Colour coding: blue at n-terminal progressing to red at c-terminal. In myoglobin, the ribbon is arranged in eight spiral or helical segments. Amino acid side chains fill the (cid:498)spaces(cid:499), which are not empty. Protein structure is organized in three (or four) levels. Primary structure: the linear sequence of amino acids. Secondary structure: regular repetitive patterns, such as the helical sections in myoglobin, that run along short sections of peptide chain (5-20. Tertiary structure: the overall pattern of 3d folding of the whole polypeptide. In myoglobin, 8 helical sections enclose a central cavity.
