MBB 222 Study Guide - Midterm Guide: Imidazole, Histidine, Hydrogen Bond

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Be able to understand and apply the definitions from the beginning of the lecture. Know its name, 3-letter code and 1 letter code. Know the name of the functional group on the side chain. Be able to draw the functional group (not the entire amino acid) Know its charge (both magnitude and direction) when de-protonated and protonated. Know what types of non-covalent interactions its capable of (h-bond, charge-charge, van der waals) These residues can be general acids or general bases: The amino acids serine, threonine, and tyrosine all have hydroxyl groups, which are classic hydrogen-bond donors. Asparagine and glutamine each have an amide group, which can participate in hydrogen bonding. Histidine has a polar imidazole ring, which can accept or donate a proton in acid-base catalysis. The histidine ring"s pka of 6. 5 can be influenced by nearby residues in a protein and can approach physiological ph. When ph and pka are close, protons can more readily be donated or accepted.

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