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Lesson 1. 1: history of drug use and development. In uence of religion: medicine men - physician/priest. Used intoxicating substances from plants to alter state of consciousness and communicate with gods ex. In uence of poisons right dose di erentiates b/w poison and remedy: west/central africa. Present day drugs derived from poisons used: amazon indigenous people dipped arrows in poison (curare) caused paralysis & death of animals. Modi ed type used by anesthetists: russia. Ground with rye into break, resulted in many deaths constriction of blood vessels. Mental frenzy, hallucinations, convulsions abortion (violent contractions of uterus): used to expedite labour in small amounts. Ergotamine (treatment of migrants) & ergonovine (arrest uterine bleeding after childbirth) In uence of ancient civilizations early chinese medicine emperor classi ed drugs by taste. Ephedrine isolated: asthma & decongestant value of ancient herbs early european medicine. Milk of mother with healthy child as remedy for sick kids. Papyri documents: textbook for medical students early greek medicine.

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