PHAR 100 Study Guide - Final Guide: Spasticity, Galantamine, Ethambutol

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Bill Racz

Document Summary

Organic nitrates, - adrenergic antagonists, calcium channel blockers. Transdermal use may allow tolerance to develop (organic nitrates). Treat hypertension (high blood presure) by lowering blood pressure. Prevent clot formation and further formation of thrombi. When naturally ocurring, are not considered to be drugs, but when takn in pill form are drugs. Inhibits viral dna replication, where in cells with hsv or vsv acyclovir is activated (selective). Bnds to ergosterol causing pore formation and membrane leakage. Reduces formation of txa2 by inhibiting cyclooxygenase-1 (cox-1) which is responsible for formation of prostaglandins. Inhibit viral protease, preventing formation of mature virus core. Inhibits conversion of angiotensin i to ii, reduced constriction of vessels. Bind to bile acids, prevents reabsorption, increase elimination of bile salts - due to enhancing biotransofrmation of cholesterol to bile acids. Increases liver"s need for ldl, decreasing ldl concentrations in the blood. Redued resistance of blood vessels, reducing blood pressure.