MICR 360 Study Guide - Midterm Guide: Cd154, Mucosa-Associated Lymphoid Tissue, Nfat

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

T or f: complements circulate in active form for speed. What is the function of c3 convertase (made by all 3 path) 1919 jules bordet: heat labile lysis activity named: complement (complements are important in lysis) No lysis in bacterium in immune serum heated to 56 . Opsonisation of particulate antigens (c3b sticks to membranes) Immune complexes = antigen + antibody these activate complement! Need to clear or else complications may occur. Binding of c1q to ig activates c1r, which cleaves/activates serine protease c1s. Igm: one (when it"s adopted staple conformation on bacterial surface) C1 complex cleaves c4 and c2 c4b and c2b (c3 convertase) Mannose-binding lectin (mbl) binds to mannose residues (instead of antibodies) on microbe surface glycoproteins or carbohydrates. Classical proteins made by the liver during inflammation (ie. mbl) Msp-associated serine proteases 1 & 2: similar to c1r and c1s c4bc2b (c3 convertase) Microbial origin (ie. gram negative bacteria, lps, fungal cell wall, etc. )