MICR 360 Study Guide - Midterm Guide: T Helper Cell, Jak 3, Interferon Type I

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

Damp: danger associated molecular patterns released upon cell death (ie. dna, rna) Comes from ourselves, from something (cid:271)ei(cid:374)g (cid:449)here they"re (cid:374)ot supposed to (cid:271)e. Both bind to pattern recognition receptors (prr) family of proteins that recognize damps and pamps to initiate intracellular signalling pathways, and modulates gene expression (ie. cytokine genes to control inflammation) Horse-shoe structure made of leucine-rich repeats (lrrs) binds ligand. Intracellular cytoplasmic tail important for signal transduction. Lps of gram negative bacteria forms a complex to signal myd88: lps binding protein: binds lps, cd14: holds lps to bring to tlr-4 ssrna (in endosome during a virus infection after being engulfed) Tra(cid:374)s(cid:272)riptio(cid:374) of inflammatory cytokine genes, and increased expression of other cell surface molecules. Signalling: jak-stat pathways: jak binds cytokines stabilizes dimerization, activation of jak dimer phosphorylation of jak, stats bind to phosphorylated jaks, stats activated through phosphorylation dimerize, translocation of stat into nucleus initiate new gene transcription. Limit inflammatory response (inhibit proinflammatory and promote healing)