MICR 270 Study Guide - Final Guide: Anaphylaxis, Poliovirus, Immunoglobulin A

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Innate immune system: non-specific does not require prior exposure to invading pathogens, external nonspecific response: areas of the body exposed to the outside environment. Internal nonspecific response: areas of the body not exposed to the outside environment. First line of defense" in the immune system. Consists of three distinct barriers: physical barriers: anything that can contact and interact with invaders (tears, mucous, cellular barriers: use of innate cells for phagocytosis. Pattern recognition receptors (prrs: display on surface of cells allows specific targeting of cells. Inflammation: occurs to localize and eliminate invading pathogens helps reduce spread and remove damaged tissues. Influx of phagocytic and other immune cells: alteration of blood flow to injured area, removal of foreign antigens, healing of damaged tissues. Signs of inflammation: calor heat, functio laesa loss of function, dolar pain, tumour- swelling, rubor- redness. Humoral b cell immunity: b cells and antibodies.

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