PHAR 300 Study Guide - Midterm Guide: Fetus, Gastric Mucosa, Nicotine
Document Summary
Life: 2 hours, caffeine: 4-5 hours (shorter in smokers due to enzyme induction, long half-life. Aspirin: 3 hours at dose, 15 hours at dose (saturated) Morphine: 2-4 hours: weak base: unionized in basic environment (more lipid-soluble, absorbed mainly in gi tract, but also in stomach, metabolized rst by alcohol dehydrogenase to form acetaldehyde, rapidly crosses blood-brain. Anti-schizophrenics: acts on meso-cortical dopamine pathway, blocking d2 receptor relieves symptoms in most, d2 receptor inhibits na channel opening through camp modulation, effectiveness is correlated with ef cacy in blocking d2. Antidepressants: act on serotonin and norepinephrine receptors, different types, monoamine oxidase inhibitors (nicotine, meth, increases [neurotransmitter] due to. Rem sleep: tolerance develops to return to normal, stop: rebound in rem sleep: nightmares. Aspirin: metabolized to salicylic acid by cleaving acetyl group. Ibuprofen: metabolized in liver by p450 system. Morphine: absorption from gi tract is slow and incomplete due to large rst-pass effect, intermediate (normorphine) has unpleasant side- effects.