BIOL 200 Study Guide - Final Guide: Proteasome, Sirtuin 1, Ubiquitin Ligase
22 Jun 2016
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You can block translation by: blocking eif4e and eif4g interaction blocking the 60s recruitment (pabp1) shortening of the poly a tail, causing mrna to be degraded. Ire-bp binds in low iron conditions to improve stability of tfr mrna (less degradation) Inhibit translation example: ferritin high iron - lots of ferritin to sequester the iron (5" utr of mrna) low iron - no translation initiation of ferritin. Ire-bp used in low iron to stop ferritin (you now want iron) Hunchback is present thought the egg (anterior crest) Nanos will block translation of hunchback in the wild type. A nanos mutant will fail in doing so, and thus the entire egg has an anterior fate (no posterior) lethal. Protein kinases accept 2 substrates to transfer a phosphate from one to another might require phosphorylation to be fully active allow it to access substrates more e ciently.
