IMED3001 Study Guide - Quiz Guide: Tunica Media, Polycystic Kidney Disease, Exsanguination
20 Dec 2020
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Can lead to exsanguination, rapidly fatal, e. g. aaa. Disturbance of blood flow in the vessel can lead to thrombus formation, which can occlude the involved vessel or one of its branches. Found at branch points of the large intracranial arteries in the circle of willis. Form in areas where there are congenital defects in the smooth muscle layer of the artery (tunica media) Nb the aneurysm itself is not usually congenital, it is the defect that is present at birth and the aneurysm develops over time. Increased risk in polycystic kidney disease, ehlers-danlos syndrome. Eg hypertension, smoking, cause aneurysm to expand over time. Compression of adjacent brain and cranial nerves. Clinically leads to headaches, double vision, loss of vision. Adults, 30-60, slightly more likely in women. Vomiting, double vision, seizures (mass effect) Approx 25% die within 24 hours of rupture. Further 25% die within 3 months.
