IMED3001 Study Guide - Final Guide: Tissue Factor, Ischemia, Spasm
15 Dec 2020
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Imed3001: pathogenesis of mi: insufficient coronary perfusion. Fixed atherosclerotic narrowing of the coronary arteries. Fissuring , ulceration, haemorrhage or rupture of atherosclerotic plaques. Tissue factor activates the coagulation pathway. Full thickness necrosis in territory supplied by a single coronary artery. Circumferential necrosis around inner 1/3 to 1/2 of the ventricular wall and may extend beyond the territory supplied by a single coronary artery. Size of vessel(s) obstructed, its site and degree of obstruction. Rapidity of onset of the obstruction. The wave of necrosis spreads from the subendocardial aspect of the ischaemic area and extends outwards. If obstruction is relieved, reperfusion may limit the damage, gives rise to eosinophilic contraction bands, or may result in reperfusion injury probably due to release of free radical. Laboratory tests for the presence of myocardial proteins in plasma. Complications of mi: sudden death, no complications, complications.
