IMED3001 Study Guide - Final Guide: Thrombus, Atheroma, Intermittent Claudication
15 Dec 2020
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Multiple risk factors have an additive effect. 2 major risk factors increases risks of ihd by 4x. 3 major risk factors increases risks of ihd by 7x. Ulceration of the atheroma with release of cholesterol emboli (atheroemboli) to occlude artery downstream. Rupture or erosion of the surface of the atheroma, causing thrombosis, leading to occlusion of the artery at that point, or the thrombus can embolise, and cause occlusion of an artery downstream. Haemorrhage into the atheroma, causing the artery to occlude at that point. Aneurysmal dilatation of the weakened artery wall. Coronary arteries become slowly narrowed: angina pectoris. Coronary arteries are suddenly occluded by thrombus on a plaque after the plaque has ruptured, or by haemorrhage into a plaque: myocardial infarction. Atherosclerotic plaques in the circle of willis. Consequences are tias (transient ischaemic attacks) and stroke. Arteries slowly narrow over time: intermittent claudication, impotence, nonhealing leg ulcers. Weakening of the aortic wall: abdominal aortic aneurysm.
