IMED3001 Study Guide - Final Guide: Pus, Necrosis, Sarcoma
14 Dec 2020
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Anywhere in body, usually head and neck. Often arise from congenital ectasias or vascular anomalies. Appear weeks after birth, grow rapidly, then involute (usually by age 10) Present and fully developed at birth. Some involute rapidly over first year of life. Occur in the skin, subcutaneous tissues, and mucous membranes of the oral cavities and lips,as well as in the liver, spleen, and kidneys. Histologically, thin-walled capillaries with scant stroma. No nuclear atypia, no invasive architecture, usually no necrosis and low mitotic activity. Benign, but can be large and compress/disrupt normal structures, often poorly circumscribed. Histologically, large, dilated spaces with bland endothelium, no intervening normal tissue between the vessels. Thrombi can form within and lead to emboli. Can be sporadic (majority) or associated with syndromes (for example. Capillary hemangiomas that present as rapidly growing red pedunculated lesions on the skin, gingival, or oral mucosa. Bleed easily and are often ulcerated.
