PHRM30003 Study Guide - Final Guide: Erlotinib, Ipilimumab, Transforming Growth Factor Beta
6 Jun 2018
School
Department
Course
Professor
Drug name
Drug class
Molecular target(s)
Mechanism/Function
Contradiction/AE/Notes
Anti
-
allergic
(4)
Telfast
Anti
-
histamine
s
Anti-allergic
H1 receptor
Competitive b
lockade of histamine binding
to H1 receptor, avoiding activation of mast
cell
H1
-
H4 receptors are
GPCRs
Not useful for colds or asthma
Chlorpheniramine
Promethazine
Sedative H1
antagonists
Sedation may be beneficial
Terfenadine
Astemizole
Non
-
s
edative H1 antagonists
Lack anti
-
muscarinic activity and GIT effects
Poor entry into CNS
Non-drowsy
Can cause sudden ventricular arrhythmia
(withdrawn)
Cetirizine
Loratadine
Newer non
-
sedative H1
antagonists
Reduced risk of unwanted cardiac effects
Omalizumab
Humanized anti
-
IgE Ab
Free IgE
Block IgE
-
dependent activation pathway
1. Bind to free IgE to decrease cell-
bound IgE
2. Decrease expression of high affinity
receptors
Very expensive
Only used to treat asthma and urticaria
Disodium
cromoglycate
(DSCG)
Mast cell stabilizers
GPR35
U
nknown
Possible agonist at GPR35
Allergen
immunotherapy
Desensitise IgE
-
dependent
pathway (tolerance)
Ig
G?
Unclear
1. Neutralise allergen, increase IgG
2. Stimulate inhibitory pathways (ITIM)
Subcutaneous immunotherapy (SCIT)
Sublingual immunotherapy (SLIT)
