PHRM30003 Study Guide - Final Guide: Secukinumab, Brodalumab, Ustekinumab
5 Jun 2018
School
Department
Course
Professor
Drug name
Drug class
Molecular target(s)
Mechanism
/Function
Contradiction
/
AE/
Notes
RA
(4)
Methotrexate
(MTX)
Sulfonamides
(SFM)
Non
-
biological DMARDs
TNF-alpha blocker
Anti-cancer
Immunosuppressant
TNF
-
alpha
Inhibit DNA synthesis
by
inhibit
- MTX: Dihydrofolate reductase
- SFM: Dihydropteroate synthetase
Supress T cell proliferation
Low dosepreferentially inhibit proliferating
cells
Cheap
Tofacitinib
“Jakinibs” = JAK
inhibitors
Non
-
biological DMARDs
JAK
JAK
STAT
cytokine expression
Decrease expression of
- IL-6
- GM-CSF
- IFN-alpha/gamma
- IL-2
- IL-15
Infliximab
Etanercept
Adalimumab(ADA)
Golimumab
Biological
DMARDs
= mAb
Anti-cytokine/cytokine
receptor
TNF
-
alpha
Tocilizumab
Biological DMARDs
Anti-cytokine/cytokine
receptor
IL
-
6R
Mavrilizumab
Biological DMARDs
Anti-GM-CSF/R
GM
-
CSF/R
Stop macrophage making
TNF
-
alpha
Aspirin
NSAIDs
Little if any
effect on disease progression
GCs
GCs
AE with systemic use
Psoriasis
(4)
Betamethsone
Topical
steroids
A
trophy
Anthralin
Coal tar derivatives topicals
Cancer
Calcipotrene
Vitamin D analogues topicals
UVB light
Phototherapy
Cancer
Retinoic acid
–
teratogenic
Vitamin A analogues
Systemic therapy
Cyclosporin
Immunosuppressant
Systemic therapy
Methotrexate
Anti
-
proliferative
Arthritis
Systemic therapy
