PHRM30003 Study Guide - Final Guide: Immune Checkpoint, T790M, Osimertinib

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olivepanda287

5 Jun 2018

School

University of Melbourne

Department

Pharmacology

Course

PHRM30003

Professor

Christine Wright

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Drug name

Drug class

Molecular target(s)

Mechanism

/Function

Contradiction

AE/

Notes

Lung

Cancer

(3)

IDO

TGF-beta

Local immunosuppressant

Increase efficacy of immune checkpoint

Ipilimumab

Immune checkpoint

inhibitor

CTLA4

Nivolumab

Immune checkpoint

inhibitor

PD1

MPDL3280A

Immune checkpoint

inhibitor

rlotinib

RTK

blocker

EGFR = HER1

First effective inhibitor

Osimertinib

RTK blocker

EGFR T790M mutant

Second generation

Invented due to single mutation T790M

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PHRM30003 Study Guide - Final Guide: Immune Checkpoint, T790M, Osimertinib

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