HUMB1004 Study Guide - Final Guide: Mesenchymal Stem Cell, Hyaline Cartilage, Bone
4 Aug 2018
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Produces rigid framework: protection, support, attachment sit for tendons and muscles that are essential for locomotion. Bone development + remodelling is continuous from pre-natal period and early childhood. 2 types depend on the bone type that is forming. Intramembranous ossification = flat bones (ribs, scapula, skull, pelvis) Endochondral ossification = most bones (long bones of arms + legs) Eventually the centrally located mesenchymal stem cells within the embryonic fibrous connective tissue differentiate into bone forming cells osteoblasts leading to the formation of ossification centres. Matrix formation phase follows osteoblasts lay down osteoid (organic part of bone collagen), some of the osteoblasts become entrapped within the osteoid and become osteocytes. Osteoid then calcifies forming slender needle like structures of spongy bone spicules. Spicules then aggregate in the form of small supporting beams/form trabeculae. The blood vessels on the outside of the spongy bone condense to form periosteum (fibrous connective sheath covering bone)
