NEUR3101 Study Guide - Final Guide: Dopamine Transporter, Neuromodulation, Vesicular Monoamine Transporter 2
Document Summary
Understand how membrane transporters operate to accumulate nts inside cells and vesicles. Be able to describe and compare the transporter systems involved on controlling levels of nts in the brain. Appreciate the physiological role of these transporters in brain function, and their potential as clinical targets for neurological disorders. Recall: volume transmission -> presynaptic and postsynaptic cells are always right next to each other. Must get dopamine into the vesicles -> vmat2 is the vesicle transporter. Dopamine must also be taken up out of the synapse -> membrane transporter (dat) Substrate binding sites are alternatively exposed to external and internal environments -> required to get polar molecule across membrane. Transport of the ions and the nt acorss the membrane. Movement against concentration gradient required to get nt into the vesicle -> need energy. For vesicles, this is done through the use of the v-atpase. Power from hydrolysis of atp to pump the protons into vesicles.
