Using the Article

Detection of saxitoxin in counterterrorism
using a commercial lateral flow immunoassay kit by Asuka Komano, Hisashi Maruko, Hiroshi Sekiguchi & Yasuo Seto. 

Answer the following question:

What was the rationale for seeing the results of the lateral flow immunoassay test strips when the saxitoxin was mixed with other compounds?

Answer the following question:

1. In your own words, explain why, if two compounds have the same LD50 value, they aren’t necessarily as toxic. Make sure to include the term Threshold in your answer. 

Using this article answer the following questions:

1. When you first started reading the article, what were your thoughts?

When answering the question, consider the following: (1) what information were the authors presenting, (2) how were they presenting the information, (3) was this information you already knew or were you learning something new?

2. Once you were halfway through the article, did any of the thoughts you had in your answer to question 1 change?

If they did change, what did they change to? Explain why they changed.

If they didn't change, explain why not.

3. Once you finished reading the article, were your thoughts any different than what you answered in question 1 and/or question 2?

If they were different, explain how they changed and why.

If they are not different, explain why they didn't change.

4. What do the authors suggest at the end of the article, after presenting all the information they did on aspirin and NSAIDs?

After you realize what they are doing at the end of the article, does it change your opinion on the information they presented throughout the article? Do you think they were totally honest with what they presented and how they presented it (did you go an read the references they cited to check up on what they presented)? Could they have possibly presented things in such a way so that your opinion of aspirin was negative and you would be more inclined to agree with their alternative?

answer the following questions:

1. When you are exposed to more than one compound, one of the following can be observed: (1) Additive, (2) Synergistic, and (3) potentiation. Define each term and give an example using values or a bar chart. 
2. Define and distinguish sensitivity, tolerance, and resistance with respect to exposure to a compound.
3. Define LD50
4. Why is it that the lower an LD50, the more toxic it is?