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History2Management2English13Business4Science15Nursing2Information Technology3Algebra4Computer Science3Accounting3Calculus30Mathematics4Physics14Chemistry136
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Question 3:

Scenario:

 You are the lead of a forensic toxicology team and calling all the shots. You have just been given a new case, where you must try and determine if John Doe, the person you are doing an autopsy on, was the victim of foul play – a suspected poisoning. John Doe arrived at the emergency room of a hospital one day ago alive but unconscious. The following samples were collected upon admission:

  • Blood (A).
  • Urine (B).
  • Hair (C).

After being admitted for one day (24 hours), John Doe died with no cause of death reported. John Doe’s body arrives at your facility for autopsy along with the samples A, B, and C. You further collect the following samples:

  • Liver (any part) (D).
  • Stomach contents (E).
  • Lungs (F).
  • Vitreous humor (G).
  • Hair (H).
  • Blood (I).
  • Urine (J).
  1. You only have enough time/money to process and analyze 4 of the samples (A-J). Indicate which 4 samples you would select and explain why you chose those samples (each sample has a letter associated with it (A-J); use this letter when answering the question). In your explanation you should discuss why each sample individually was chosen and any benefits there might be from the samples complementing each other. Also include in your answer the key factor that must be considered with respect to all samples (ADME) and explain how you accommodated this with your sample choices.

 

2. Once you have chosen your samples, you will need to perform some form of chromatography on each one before you can start to analyze them for any poison. Indicate which method of chromatography you would choose for each sample. You can use more than one method of chromatography on a single sample or use the same method on all samples – as long as you explain how that method of chromatography works and why it’s appropriate for each sample. As part of your answer, discuss if each sample would need pre-treatment before being subjected to chromatography and what the pre-treatment would be. 

 

3. Now that you have prepared your samples you must visualize and quantify your results using mass spectrometry. Select an ionization method for each sample that you prepared in question 2 above, describe how it works, and why it is ideal for that specific sample.

 

4. Describe what you need to do in question 3 above to be able to quantify your sample. 

 

5. What if you were presenting your mass spectrometry results in court and had a peak at an m/z of 542.3 and you stated in your findings that this corresponds to unique fentanyl analogue, which killed John Doe. Describe what additional work you must do to support this conclusion, how it works, and why it can provide definitive proof that the compound is in fact the unique fentanyl analogue. 

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fQuestion:

2.Fission is a nuclear process in which small nuclei are combined into larger nuclei, releasing energy.

True

False

3.Which of the following isotopes is used for irradiation of food?

Thorium-228

Plutonium-238

Cobalt-60

Uranium-233

Iodine-131

4.An isotope undergoes beta decay. The daughter nucleus will have

a lower atomic number than the parent nucleus

an atomic number twice as high as the parent nucleus

the same atomic number as the parent nucleus

a higher atomic number than the parent nucleus

5.

What role does cadmium metal (Cd) play in a nuclear reactor?

transfers heat from the condenser to the environment (cooling tower)

slows down the fission neutrons (moderator)

undergoes fission (fuel rods)

controls chain reaction (control rods)

transfers heat from the reactor to the heat exchanger (primary coolant)

6.Which type of radiation is best suited for external radiation therapy

gamma

beta

neutron

alpha

7.Which of the following daughter isotopes will be produced after the radioactive decay of actinum-227 by alpha particle emission?

Polonium-218

Astatine-211

Thorium-226

Francium-223

Radium-226

8.Complete the following equation:235/92U---------->4/2He +.............

a) 231/90 Th

b) 231/91Pa

c)235/93 Np

d)235/92 U

e)236/93 Np

9.Alpha particles are identical to

helium nuclei.

hydrogen atoms.

electrons.

helium atoms.

protons.

10.Which of the following is an advantage of nuclear power plants over coal-burning plants? Nuclear plants:

form numerous radioactive fission products.

use more fuel.

produce more thermal pollution than coal plants.

do not pollute the air with SO2, soot, and fly-ash.

11.

Which type of nuclear process requires an extremely high temperature (millions of degrees)?

alpha decay

beta decay

positron emission

fission reaction

fusion reaction

12.If a sample of nobelium has an activity of 32 Ci and if the half-life of nobelium is 102 s, then in how much time will its activity become 4 Ci?

120 s

205 s

405 s

287 s

306 s

13.Radioactive elements are used for:

medical treatment.

determining age of fossils and rocks.

all of the above

medical diagnosis.

generating electricity.

15.Protactinium-231 is produced as a daughter isotope after the radioactive decay of _____ by alpha particle emission.

neptinium-235

plutonium-238

uranium-232

Americium-241

curium-243

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1. (1 point) What might be damaged by ionizing radiation? * paper soft tissue wood lead

2. (1 point) When an atom emits an beta particle, what is the change in the atomic number? * no change decrease by 1 decrease by 2 increase by 1 increase by 2

3. (1 point) What is the change in atomic mass caused by the emission of gamma radiation? * no change decrease by 1 decrease by 2 increase by 1 increase by 2

4. (1 point) Which of the following materials would effectively stop gamma radiation? * one foot of concrete single sheet of paper thin pieces of wood three inches of lead

5. (1 point) When the ratio of neutron-to-proton dictates that a neutron must break down it will form _________. * A helium nucleus An alpha particle A proton and an electron Two protons

6. (1 point) What determines the type of decay if a nucleus falls outside the band of stability? * the ratio of alpha particles to beta particles the ratio of beta particles to alpha particles the ratio of neutrons to protons the ratio of protons to neutrons

7. (1 point) A positron is emitted when ____________. * an alpha particle forms a beta particle forms proton converts to a neutron neutron converts to a proton

8. (1 point) How does an atom with too few neutrons relative to protons undergo radioactive decay? * by converting proton to a neutron by converting a neutron to a proton by emitting an alpha particle by emitting a beta particle

9. (1 point) How much of the original sample would remain after two half lives have past? * There would be nothing of the original left There would be half of the original sample still there There would be one quarter of the sample still present There would only be one eighth of the original sample still present

10. (1 point) What is the approximate half life of carbon- 14? * hundreds of years thousands of years million of years billion of years

11. (1 point) A reaction where a heavier nucleus splits into smaller nuclei is called ___________. * a chemical reaction background radiation fission fusion

12. (1 point) __________ and ___________ are used as moderators to capture neutrons in a nuclear reactor. * Cadmium and other metal Carbon and water Liquid sodium and water Plutonium and neptunium

13. (1 point) For a person working in a place where they might be exposed to radiation a _________ is routinely used to check their exposure. * film badge Geiger counter moderating rod scintillation counter

14. (1 point) Radioisotopes are used to do all of the following except __________. * analyze matter. diagnose medical problems. improve the flavor of food. treat diseases. study plant growth. Open response questions: Answer the following with complete sentences or if math is involve show the work

15. (3 point) The radioisotope radon-222 has a half-life of 3.8 days. How much of a 198.6 g sample of radon -222 would be left after approximately 23 days? ( Show your work) * Your answer

16. (3 point) How can an element be artificially transmuted? Give an example that has an element and what it is transmuted into. * Your answer

17. (4 point) Why does the mass and charge of an alpha particle make it less penetrating than a beta or gamma? Discuss both the mass and the charge(2 points each). *

Answer: Soft tissue may be damaged by ionizing radiation. The atomic number de...
Answer: The particle that results in no change in nuclear charge when emitted ...
Answer: Water Proton Lead (Pb) Radon
Answer: Beta radiation Beta particle Neutron Neutron Much greater.

Nuclear Decay Equations

Learning Goal:

To predict the products of alpha emission, beta emission, positron emission, and electron capture.

Radioactivity is the spontaneous emission of radiation from an unstable nucleus. There are five major types of radioactive decay:

Alpha (α) radiation consists of helium nuclei. The helium nucleus is a small particle containing two protons and two neutrons (42He).

Beta (β) radiation consists of electrons. In nuclear equations, the standard format for representing a beta particle using superscripts and subscripts is 0−1e.

Positron emission results from the conversion of a proton in the nucleus to a neutron. The ejected positron is a particle that has the same mass as an electron but an opposite charge. In nuclear equations, the standard format for representing a positron using superscripts and subscripts is 01e .

Electron capture is the capture of an inner shell electron by a proton in the nucleus. The process emits gamma (γ) radiation and results in a proton converting to a neutron. Gamma radiation consists of high-energy electromagnetic radiation.

Gamma (γ) radiation consists of high-energy radiation, and contains no particles and thus they have no mass. In nuclear equations, the standard format for representing gamma radiation using superscripts and subscripts is 00γ.

Balancing a decay equation

There are two main rules to remember when balancing nuclear equations:

The total of the superscripts in the reactants and products must be the same.

The total of the subscripts in the reactants and products must be the same.

For an isotope of an element, the superscripts are mass numbers, and the subcripts are atomic numbers:

Mass number ⟶ AAtomic number ⟶ Z X ⟵ Chemical symbol

Where the mass number (A) is the sum of the number of proton and number of neutrons in the nucleus, atomic number (Z) is the number of protons in the nucleus, and chemical symbol (X) is the symbol of the specific element.

Part A

Identify the nuclide produced when americium-241 decays by alpha emission:

241 95Am→42He + ?

Express your answer as an isotope using prescripts.

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Part B

Identify the nuclide produced when phosphorus-32 decays by beta emission:

3215P→ 0−1e + ?

Express your answer as an isotope using prescripts.

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Part C

Identify the nuclide produced when fluorine-18 decays by positron emission:

18 9F→01e + ?

Express your answer as an isotope using prescripts.

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Part D

Identify the nuclide produced when thallium-201 decays by electron capture:

201 81Tl+ 0−1e→00γ + ?

Express your answer as an isotope using prescripts.

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