BIBC 100 Study Guide - Ramachandran Plot, Random Coil, Entropy
Document Summary
Use the kyte-dooli. le hydropathy index and sidechain chemistry to predict the roles a side chain can play in a folded protein. Recognize the n and c terminus of a polypep>de. Use a ramachandran plot to evaluate the entropic cost of a polypep>de achieving a de ned, folded structure. Connect ramachandran plots, and angles, and hydrogen bonding to explain why an -helix is thermodynamically favorable. Connect ramachandran plots, and angles, and hydrogen bonding to explain why -sheets are thermodynamically favorable. Compare a random coil to the na>ve, folded state of a protein. Connect the hydrophobic e ect and vwis to protein folding. Connect intramolecular hydrogen bonds to burying the backbone and hydrophilic sidechains in the hydrophobic core. Connect folding and the overall g of a protein. Use lone pair electrons, electronega>vity, and charge to model the electron distribu>on across a molecule. Given an atom in a molecule, name the electrosta>c interac>ons it can par>cipate in.
