Pharmacology 2060A/B Study Guide - Midterm Guide: Hmg-Coa Reductase, High-Density Lipoprotein, Low-Density Lipoprotein
8 Dec 2022
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We obtain cholesterol through dietary sources (exogenous cholesterol) or through synthesis (endogenous cholesterol) which occurs primarily in the liver. primary function of lipoproteins is to transport cholesterol and triglycerides in the blood. Allow recognition by cells which may bind and ingest lipoproteins. Lipoproteins that contain apolipoprotein a-i transport cholesterol from non-hepatic tissue back to the liver, lipoproteins that contain apolipoprotein b-100 transport cholesterol to non-hepatic tissue. Vldl"s deliver triglycerides from the liver to adipose tissue and muscle. They have a triglyceride rich core and account for almost all of the triglyceride content in blood. contain one apolipoprotein b-100 molecule, which allows them to bind to cells and transfer their lipid (mostly triglyceride) to cells. Ldl"s deliver cholesterol to non-hepatic tissue, one apolipoprotein b-100 molecule, which allows them to bind to cells and transfer their lipid (mostly cholesterol) to cells. Hdl"s deliver cholesterol from non-hepatic tissue back to the liver.
