PHARMACOLOGY Lecture Notes - Lecture 1: Tullahan River, Intrauterine Growth Restriction, Gestational Diabetes
Document Summary
Remember that humans are not used as a host or a sample for a certain type of research/studies involving medications / drugs / agents: the agent acts in an unaltered form in an experimental model. Although the criteria may not be required to establish teratogenicity, the following tenets must be considered: Certain types of syndromes of defect are associated with this type of medication . Outweighs benefits vs risks: the agent must cross the placenta in order to affect the developing fetus (in cases of pregnancy, exposure must occur during a critical development period. Teratogen agent that acts during embryonic or fetal development to produce a permanent alteration of form or function. Thus, these recognized factors as: chemical substance medication, physical or environmental heat or radiation, maternal metabolite diabetes or phenylketonuria, maternal infection cytomegalovirus, hadegen is an agent, that interferes with the organ maturation and function.