BIO 365S Lecture 29: Lecture 29

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16 May 2018
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Chapter 20
Water ions, and acid-base balances
More than 1 system got involved.
Itegrated sste, od does’t are hih sste fies the prole. Whe pH is out of
balance, activates more than one system to fix it.
Mainly focus on respiratory and renal. Behavior also plays a role.
CO2 imbalance respiratory, subject to neural control, quick system.
pH impabalance renal, subject to hormonal control, slow system.
Integrated responses to changes in blood volume and blood pressure
Low blood pressure stimulates thirst
Behavior, talks to cortex, makes you thirsty and drink more water for increase of water intake.
Eventually wants to maintain homeostasis ultimate goal.
Water Balance
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Output water cannot be replaed, it’s goe. So ou hae to itake fro eiroet . Do’t
have to drink 2.5L of water, but rather drink about 1.8L of water, and the rest comes from food
and metabolism processes.
Pathological water loss (sweating and diarrhea) affect body homeostasis: increase osmolarity of
plasma, decrease blood volume, and decrease blood pressure.
If pathological loss of blood (like hemorrhaging): affect body differently because losing isotonic
volume.
Kidneys cannot restore lost volume. They only conserve fluid!
Water loss cannot be replaced by conserving water. Can shut down the volume loss in urine
arrow, and sweating (if in desert, can die of extreme heat shock faster). Water still gets lost, so
need to drink water.
OSMOLARITY CHANGES THROUGH THE NEPHRON
Blood being handled by kidney, which nephron filters plasma.
Once moved into nephron, blood = lumen. Lumen environment very similar to plasma.
Environment osmolarity is higher when going deeper. Outside higher osmolarity = help water
reabsorption to dilute the environment, but water actually doesnt have time to dilute
actually goes to the capillaries surrounding the loop of Henle and gets carried away to blood
do’t at to ess up the edulla’s oetratio. Whe oe ak fro the otto loop
(highest osmolarity), lowers osmolarity, and membrane is impermeable so water cannot move
back so only ions move back. In the distal tubule = adjustable in body, can make body take
more water back if dehydrated (highly concentraed) or take more water if too much water
(urine highly diluted), and if body too acidic (acidosis) then urine will be more acidic (body
dumps more H+ into urine) and same thing with basicity.
Vasopressin (AVP or ADH): control water reabsorption in the collecting duct.
Pituitary gland: oxytocin and vasopressin.
Peptide hormone, (steroid hormones found in gonad and adrenal cortex, need plasma
protein helper to be transported in plasma, can be freely diffused through plasma
membrane and bind with intracellular receptor to trigger intracellular receptor, use
cAMP.
Vasopressin only binds cAMP.
With AVP: collecting duct is freely permeable
to water. Urine is concentrated.
Vasopressin: function if for water reabsorption.
When water moves out, it quickly moves into vasa reta to oe ak ito lood, does’t hae
a chance to mess up the environment.
Without vasopressin, water ducts are closed as it goes through the distal tubule, and so no
water gets reabsorbed and dilute urine is moved through the collecting duct.
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Document Summary

I(cid:374)tegrated s(cid:455)ste(cid:373), (cid:271)od(cid:455) does(cid:374)"t (cid:272)are (cid:449)hi(cid:272)h s(cid:455)ste(cid:373) fi(cid:454)es the pro(cid:271)le(cid:373). Whe(cid:374) ph is out of balance, activates more than one system to fix it. Co2 imbalance respiratory, subject to neural control, quick system. ph impabalance renal, subject to hormonal control, slow system. Integrated responses to changes in blood volume and blood pressure. Behavior, talks to cortex, makes you thirsty and drink more water for increase of water intake. Eventually wants to maintain homeostasis ultimate goal. Output water cannot be repla(cid:272)ed, it"s go(cid:374)e. so (cid:455)ou ha(cid:448)e to i(cid:374)take fro(cid:373) e(cid:374)(cid:448)iro(cid:374)(cid:373)e(cid:374)t . Do(cid:374)"t have to drink 2. 5l of water, but rather drink about 1. 8l of water, and the rest comes from food and metabolism processes. Pathological water loss (sweating and diarrhea) affect body homeostasis: increase osmolarity of plasma, decrease blood volume, and decrease blood pressure. If pathological loss of blood (like hemorrhaging): affect body differently because losing isotonic volume. Water loss cannot be replaced by conserving water.

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