BIO 320 Lecture Notes - Lecture 5: Sphingolipid, Sphingosine, Hydrophile

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26 Jan 2017
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Eukaryotic cells are highly compartmentalized, with many different membrane-bound compartments. Selective chemical barrier (to hydrophobic vs. hydrophilic molecules) Encapsulates specialized compartments that have specialized functions (e. g. , mitochondria that contain proteins needed for oxidative phosphorylation) Supports 2d diffusion of molecules in membrane. Lipids and proteins , on average very roughly 50% each in mass, but can vary a lot from one kind of membrane to another. Lipid (hundreds of different kinds), 3 major classes: 1. All lipid molecules in cell membranes are amphiphilic/amphipathic (i. e. , one part hydrophobic [nonpolar] and one part hydrophilic. 4 major phospholipids within the membranes of mammalian cells (many, many others not shown) Phosphoglycerides: ps has net negative charge, pi (not shown here) is a less abundant phospholipid that has important signaling roles. Sphingomyelin: fatty acid tail in sphingo-myelin tends to be longer and straighter. Phosphoglycerides can flip-flop only with help of the enzymes flippase and scramblase.

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