MCB 300 Lecture Notes - Lecture 36: Virulence Factor, Cell Membrane, Periplasm

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In order for the microbes to be functional, they need to be able to secrete their toxins to hijack the host cells. For a long time, people used to think that the only virulence factors were the toxins that were secreted but secretion itself is a virulence factor because without secretion, there would not be very effective pathogens. Without an effective means of selectively delivering virulence, factors to the proper host environment, bacteria cannot exert their virulence properties and therefore cannot be pathogenic. There are many different secretion systems that are used by microbes, some of which are used by both gram + and gram - cells, and some that are specifically used by the gram - cells. Gram + cells only have one plasma membrane and then they have a thick layer of pg outside of the membrane. Gram - cells have two plasma membranes with a pg layer in the middle.

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