CHEM 312 Lecture Notes - Lecture 31: Cisplatin, Testicular Cancer, Gadolinium
5 May 2019
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Chem 312 lecture 31 - metals in medicine. Gadolinium (gd) - radioisotope tracers, mri contrast agents. Anticancer drug that was approved by the fda in 1973. Used for treatment of sarcomas, carcinomas, lymphomas, bladder, cervical, and germ cell tumors. It also improved the cure rate of testicular cancer from. 1965: rosenberg saw inhibition of cell growth by cisplatin. In order to synthesize this, you need to start with pt(cl)4 and then add two equivalents of cl. You cannot start with pt(nh3)4 and then add more nh3 because cl is a stronger trans effector and you would get trans platin. Cisplatin binds to dna and folds it until cannot be replicated. Therefore it stops replication and it stops the cell from replicating. One cl is displaced by h2o and then it ends up binding to dna where the two cls were previously. It binds to the n7 position of the purines and n7 replaces the water in the aquated cisplatin.
