Pharmacology 3620 Lecture Notes - Lecture 14: Bone Marrow Suppression, Cisplatin, Carboplatin
6 Jan 2021
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Includes cisplatin and carboplatin: characterized by a central pt ion, surrounded by chloride and ammonium groups, cellular uptake through active transporters. In the cytoplasm, the chloride ions dissociate, generating an active complex that reacts with dna: non cell-cycle specific, but greater toxicity in g1 and s-phases, covalent binding of platinum compounds to dna causes and inter- or intra-strand. Inhibition of dna and rna synthesis: enzymes cannot use these dna strands as templates inhibition of replication and transcription, normal functions of the cell become disrupted. In many cases dna repair does not occur properly because the damage is too extensive can lead to cell cycle arrest or cell death. Act on all rapidly dividing cells (normal and tumour cells) Act on specific molecular targets that lead to or contribute to cancer. Deliberately chosen to interact with their molecular target of the tumour cells. Cytotoxic or cytostatic (prevent the growth of the cell)
