CBIO 3400 Lecture Notes - Lecture 3: Actomyosin Ring, Amoeboid Movement, Immunoglobulin Light Chain
8 Feb 2019
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Document Summary
Myosin: molecular motor of the cell: myosin is the name for an expanded gene family of motor proteins, mechanochemical enzyme because it uses atp to do work. Know the parts of a myosin motor: head (motor domain-bind actin and atp, neck (lever arm- undergoes movements during force generation, tail (may contain dimerization motifs and cargo binding domains) 3 processed need to know in myosin-ii: actin retrograde flow (know the cycle) Cells want to move: going towards + end, grabbing the actin filament keeps it from being pulled back this makes it stable. Once stable, the actin can push on the membrane. Animation of myosin mechanochemical cycle: two motor heads, hydrolyzes atp. Once engages with actin, it will release the inorganic phosphate. Atp has the effect of allowing it to range forward and release actin: binding of nucleotide, hydrolysis of nucleotide, etc, each step causes a different conformational change in the myosin motor.
