MCB 2210 Lecture Notes - Lecture 14: Kinesin, Rigor Mortis, Coiled Coil
31 Oct 2016
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Document Summary
Myosin: myosin motor proteins move along actin filaments by coupling the energy from atp hydrolysis to conformational changes, they are considered mechanochemical enzymes. They convert chemical to mechanical energy: they myosin superfamily consists of at least 15 classes (i-xv) based on sequence homology in the head (motor domains, most myosins are ( + ) end directed motors. Myosin composition: myosins are composed of heavy and light chains, the heavy chains have head, neck, and tail domains, the head (motor) domain contains the actin binding and the. Atpase activities: the neck domain has a regulatory function and is the site of attachment for the regulatory and essential light chains or (calmodulin, the tail domains differ between myosins and determine specific properties of each one: Whether it will be a monomer or dimer. And whether it will be polymerized into thick filaments: myosin ii was first described as the motor protein in muscle that powers contraction.
