HUN 2201 Lecture Notes - Alcoholic Liver Disease, Fluid Ounce, Blood Alcohol Content

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Occurs quickly, although food reduces contact with stomach lining and slows stomach emptying, thus decreasing the rate at which alcohol enters the small intestine: once absorbed, enters bloodstream. Blood alcohol level depends on difference between rates of absorption and elimination. Peak blood concentrations = 1 hour after ingestion: b. a. c. determined by weight, gender, speed of consumption, alcohol metabolism kind and quantity of beverage, food consumed with it, 2 primary metabolic pathways, alcohol dehydrogenase adh pathway [cytosol] Adh: enzyme found primarily in liver and stomach that helps break down alcohol into acetaldehyde, then converted to acetyl-coa. Reactions release high-energy electrons, form nadh derived from: although these processes produce atp, high levels of nadh niacin. slow the citric acid cycle. Acetyl coa from alcohol, carb, and fat metabolism is used to synthesize fatty acids that accumulate in the liver: constant rate of breakdown, microsomal ethanol-oxidizing system [microsomes of smooth er] Important when greater amounts of alcohol are consumed.

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