BIO 198 Lecture Notes - Lecture 36: Gamete, Tay–Sachs Disease, Genetic Drift

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All alleles originated with mutations, if the mutations for that disorder keep reoccurring over and over agai(cid:374), the(cid:374) you"d get so(cid:373)e e(cid:395)uili(cid:271)(cid:396)iu(cid:373) (cid:271)et(cid:449)ee(cid:374) the (cid:373)utatio(cid:374)s a(cid:374)d the(cid:374) (cid:374)atu(cid:396)al sele(cid:272)tio(cid:374) that sele(cid:272)ts against the mutation. The mutation will change the frequency very slowly. A a, big a is the normal allele and little a is the mutant/disease recessive allele for a disorder. The mutation rate is u or the fraction of big a alleles that mutate to little a alleles in each generation. There will also be selection against the deleterious mutation/allele and we get to equilibrium between mutation and selection where selection wants to decrease the mutant allele while mutant wants it. When these two forces just balance: how is selection acting on the little allele. Recessive disorders: q is the frequency of little a. If dominant disorder where big a allele is the deleterious allele, a a and little a is the normal allele and mutation rate is u.

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