BIO 202 Lecture Notes - Lecture 8: Cori Cycle, Oligosaccharide, Glycation
20 Sep 2016
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They catalyze the formation of glyosidic bonds and oligosaccharides. Name the amino acids which are covalently linked to oligosaccharides. Contrast n-linked glycosylation with o-linked glycosylation with respect to cellular localization. N glycosylation begins in the er and continues in the golgi. O glycosylation takes place mostly in the golgi. Proteins destined to the lysosome have are high in mannose chains which is added in the golgi. When the golgi is missing the enzyme phosphotransferase, synthesis of mannose is blocked and therefore proteins going to the lysosome never get there. Name and contrast the two types of diabetes. Type 1- insulin dependent, patients unable to synthesize adequate amounts of insulin. Type 2- non-insulin dependent, patients are resistant to the action of insulin. Its synthesized in the pancreas by beta cells which is stimulated by high blood glucose levels. Define non-enzymatic glycation and what are the physiological consequences of uncontrolled glycation.
