BIO-1 Lecture Notes - Lecture 21: Internal Transcribed Spacer, Tinea Barbae, Microsporum
Document Summary
Conserved genes such as ribosomal small and large subunits for phylogeny. Speciation based on more variable genes such as rdna internal transcribed spacer (its), other sequences such as beta tubulin, actin. Phenotypic methods lack the discrimination compared to molecular methods. Cryptic species: species that are not distinguishable by their phenotype. Allogeneic hsct 2nd most common cause of invasive fungal infection. Columella: part of sporangiophore that protrudes into sporangium. Sporangium: specialized organ that produces asexual spores. Some dermatophytes in the genus trichophyton and microsporum are nonpathogenic. Differentiated based on spore morphology and other microscopic features. Teleomorph in genus arthroderma (ascomata with asci) T. capitis head, mainly in children, adults can be carriers. T. unguium infection of the nail. Tinea unguium dermatophyte infection of the nail. Predisposing conditions include increasing age, diabetes, tinea pedia, tight fitting shows, immunocompromised, trauma. Cd4 counts < 200 cell/mm3 or cd4/cd8 of < 14% Incidence is now < 1 case per 100 years.
