BIO-1 Lecture Notes - Lecture 17: Cryptococcus Neoformans, Aspergillus Fumigatus, Biopharmaceutical
Document Summary
Compared to plants, mammals are resistant to fungi. Temperature of humans is 36 37 degrees c. Many fungi prefer 25 30 degrees c. Complex immune system that prevents growth of conidia when inhaled. On host body but does not grow or use host body for nutrition. Uses compounds from host body but does not cause any damage. Growth in host body without invasion or host response. Multiplication in tissue without functional and structural damage. Damage to host tissue resulting from fungal growth. Facultative pathogens in humans as infection from the environment; has specific. Opportunistic infection: virulence to cause disease in humans. Inoculation in human (e. g. trauma) with immune response. Disease progression due to host factors such as immunosuppression. Only found in mammals (e. g. pneumocystis jirovecii), some dermatophytes. Example of two life cycles adaptation to the environment and to the host. Phaeohyphomycosis: presence of pigmented hyphae in tissues. Indwelling catheters (central venous lines, dialysis lines)
