NUR 326 Lecture Notes - Lecture 11: Bronchospasm, Artificial Heart Valve, Itch
Document Summary
Causes of clot formation: blood stasis, platelet aggregation, blood coagulation, atrial fibrillation (carotid, brain, heart, dvt, lungs) Intrinsic pathway cascade of clotting factors leading to formation of clot inside vessel (works from inside out) Hagemen factor (factor xii) activiated when there is an injury: activated from exposed collagen, activated factor xi (plasma thromboplastin antecedent, activates a cascading series of coagulant substances. Letter a gets attached when a factor is activated so now xlla. Breaks down fibrinogen to fibrin plugging injury. Hageman factor (factorxii) activated: clot formation process, clot dissolving process. Inflammatory process: extrinsic pathway cascase of clotting factors leading to formation of clot outside of vessel (works from outside in) Causes blood outside the vessel to clot. Stimulated to release thromboplastin actives cascade for clotting outside the vessel. Plug formed and clot now inside and outside the vessel. Disorders affecting blood coagulation: overproduction of clots thromboembolic.
