KNES 433 Lecture Notes - Lecture 13: Von Willebrand Factor, Coagulation, Thromboxane A2
11 Apr 2018
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Lecture 13 coagulation: blood coagulation: a process that changes circulating substances within the blood into an insoluble gel. The gel plug leaks in blood vessels and stops the loss of blood. Then, fibrin mesh/clot forms and entraps the plug. Eventually, need dissolution of clot by plasmin for normal blood flow to resume following tissue repair: plug with only platelets = white plug. Inflammatory foci are rich in proteases released by neutrophils (serine proteases) and macrophages (metalloproteases): thrombin is generated at the site of vascular damage. Most common 9/10 hemophilia patients and x-linked), ix (b x-linked), or xi (c could be from either parent). Viii is very important cannot complete cc (needed for factors x, ii, and i: symptoms include continuous bleeding after minor surgeries (like circumcision) or tooth extraction, presence of blood in urine/stool, and bruises/swelling of joints. Extra info to help with written questions on midterm. Because of thrombin we also get platelet aggregation happening.
