PYSO 001 Lecture Notes - Lecture 10: Moe Williams, Carboxyhemoglobin, Oxygen Toxicity
12 May 2020
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Two forms of oxygen in blood: dissolved gas 0. 3 ml/100ml = 1. 5% of total oxygen in blood. Not enough oxygen to keep us alive even at rest: bound to hemoglobin (hb) 19. 7 ml/100 ml = 98. 5% of total oxygen in blood. Hemoglobin (hb): oxygen carrying molecule in red blood cells (rbc) Deoxyhemoglobin (reduced) = o2 not bound to hb. 4 globin polypeptide chains (2 and 2 ), 4 heme groups each bound to iron (fe2+) Oxygen binds fe2+, so hb can carry up to 4 oxygen molecules. ~280 million hb/rbc x 4 oxygen = >billion oxygen molecules/rbc. Androgens stimulate rbc and hb production (males have higher hematocrit) Hemoglobin can be altered or bind to other gases: Methemolgoblin: fe 2+ oxidized to fe 3+ can"t bind oxygen (certain drugs can this) Carboxyhemoglobin: hb bound to co (carbon monoxide) co poisoning. Co binds hb ~210x stronger than it binds oxygen co poisoning even at low co concentration.
