BIOL 003 Lecture Notes - Lecture 6: Dna Replication, Okazaki Fragments, Moe Williams
Document Summary
2 strands of nucleotides (sugar (deoxyribose) + phosphate + nitrogenous base = 1 nucleotide) Cytosine / guanine 3 hydrogen bonds. Labeled according to carbons that connect to phosphates. 5" to 3" or 3" to 5". 5" of one strand lines up with 3" end of other strand. Assembles in 5" to 3" direction only (i. e. runs from 3" to 5" of parent strand) Leading strand: built on 3" end of parent strand continuous synthesis. Lagging strand: build on 5" end of parent strand discontinuous synthesis. Dna synthesis begins at fork, has to keep jumping back". Describe how the information in dna is transcribed into protein. Dna mrna (transcription) mrna protein (translation) Transcription: initiation rna polymerase (works in 5" to 3" direction) binds to promoter (marks initiation site) and unwinds dna strand, elongation rna polymerase continues to unwind dna, produces rna by adding nucleotides to dna 3" end.
