BIOS 4500 Lecture Notes - Lecture 27: Lipid Peroxidation, Aica Ribonucleotide, Adipose Tissue

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Insulin normally stimulates glucose uptake, while glycogen inhibits it. Drugs, like metformin and aicar, can also stimulate glucose uptake in skeletal m. , independent. Lipid overload in visceral fat-> no more fat storage-> increased levels of free fatty acids-> toxic. Those w/ diabetes have increased fa (fatty acid) uptake and decreased fa oxidation. Individuals w/ type ii diabetes often is a result of sedentary lifestyles-> less fa oxidation. W/ exercise there can be an increase in fa oxidation to help compensate for the increased fa uptake. Part 2: role of counterregulatory hormones and responses to energy challenges. The (cid:271)rai(cid:374)"s main source of fuel is glucose. 20% of all energy intake in adults, and 40% in the growing child brain. Glycogen can be used as carbohydrates as fuel for m. and all other tissues. 5" amp-a(cid:272)tivated protei(cid:374) ki(cid:374)ase/5" ade(cid:374)osi(cid:374)e (cid:373)o(cid:374)ophosphate-activated protein kinase is an enzyme that plays a role in cellular energy homeostasis.

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