BIOL 1119 Lecture 22: AP Class 20:21

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In metabolically active tissues, the following 3 factors lead to more o2 released from. Hbo2: blood pco2: active tissue has increased pco2, temperature: active tissue has increased temp, bohr effect: active tissue has increased lactic acid and co2, which lowers ph. Protons and co2 bind to globin portion of hb and alter conformation of hb molecule; temp also alters shape. These 3 factors do not matter as much as in the lungs for the high po2 in lungs means: shifting the curve to the right one has a small effect on hb saturation. In systemic capillaries, where po2 is lower, the effect causes a strong decrease in saturation of hb with o2 at a given po2. Three factors combine are much of the reason that % saturation of hb with oxygen decreased in very metabolically active tissue as compared to resting tissue. Need rapid unloading of oxygen in metabolically active tissue, which have an increased demand for o2.

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