POL SCI 2 Lecture Notes - Lecture 19: Neural Tube, Radial Glial Cell, Cell Migration
Document Summary
Lecture 7: neurodevelopmental conditions could arise when neurons do not migrate correctly, to study neural migration model organisms are usually used, to visualise the process transparent embryos can be useful; c. elegans and zebrafish. Ex-vivo experiments can also be used, here cells are taken out and cultured in conditions similar to in vivo condition- but can never truly replicate this, hence tend not to have primary focus. The main type of mammalian experiments is therefore labelling progenitor cells: the c. elegans have less then 1000 cells total, 300 neurons. It has also the added benefit that every cell in the c. elegans had been identified and linage experiments have been completed (on every cell). Its embryo is also complete transparent which means that the cell migration patterns can be visualised easily: the zebrafish is more complex than the c. elegans the lateral line plasmodium is particularly use to study cell migration here.
